A positive modulator of the small conductance calcium-activated potassium channels SK2 and SK3 (EC50s = 14 and 5.6 µM

CyPPA – 10 mg

Brand:
Cayman
CAS:
73029-73-9
Storage:
-20
UN-No:
Non-Hazardous - /

CyPPA is a positive modulator of the small conductance calcium-activated potassium channels SK2 and SK3 (EC50s = 14 and 5.6 µM, respectively).{25556} It is inactive on both SK1 and the intermediate conductance calcium-activated potassium channel, IK.{25556,25557} At SK3, CyPPA increases the apparent calcium-sensitivity of channel activation, changing the EC50 value of calcium activation from 429 to 59 nM.{25556} CyPPA is used to evaluate the roles of SK2 and SK3 in such diverse processes as memory encoding, uterine muscle contraction, and dopamine signaling.{25559,25558,25560}  

 

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Description

A positive modulator of the small conductance calcium-activated potassium channels SK2 and SK3 (EC50s = 14 and 5.6 µM, respectively); inactive on both SK1 and IK; increases the apparent calcium-sensitivity of channel activation of SK3, changing the EC50 value of calcium activation from 429 to 59 nM

Formal name: N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine

Synonyms: 

Molecular weight: 285.4

CAS: 73029-73-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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