A type II pyrethroid insecticide; prolongs opening of sodium channels resulting in membrane depolarization and a conductance block of the insect nervous system; reduces survival of ticks in vitro (1-1.5 mg); reduces survival of lice in sheep fleece and prevents re-infestation in contact-challenged sheep (5 and 10 ppm); induces developmental neurotoxicities in zebrafish (50 to 200 μg/L); induces Parkinson's disease-like neurodegeneration in rats (15 mg/kg twice weekly for 24 weeks)

Cypermethrin – 50 mg

Brand:
Cayman
CAS:
52315-07-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Cypermethrin is a type II pyrethroid insecticide.{40965,40966,40967,40968} It prolongs opening of sodium channels resulting in membrane depolarization and a conductance block of the insect nervous system, and point mutations in sodium channels induce cypermethrin-resistance in house flies, cockroaches, and mosquitos.{40967} Cypermethrin (1-1.5 mg) reduces survival of ticks (H. anatolicum) in vitro in a concentration-dependent manner.{40966} Topical administration of cypermethrin reduces the number of ticks on infested cattle. Cypermethrin (5 and 10 ppm) reduces survival of lice (D. ovis) in sheep fleece and prevents re-infestation in contact-challenged sheep for 7 and 19 weeks, respectively.{40965} It induces developmental neurotoxicities in zebrafish, increasing mortality and edema and inducing body-axis curvature when used at concentrations ranging from 50 to 200 μg/L.{40969} Cypermethrin (15 mg/kg twice weekly for 24 weeks) also induces Parkinson’s disease-like neurodegeneration in rats, decreasing locomotor activity, dopamine production, and the number of tyrosine hydroxylase positive (TH+) neurons in the substantia nigra.{40968}  

 

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Description

A type II pyrethroid insecticide; prolongs opening of sodium channels resulting in membrane depolarization and a conductance block of the insect nervous system; reduces survival of ticks in vitro (1-1.5 mg); reduces survival of lice in sheep fleece and prevents re-infestation in contact-challenged sheep (5 and 10 ppm); induces developmental neurotoxicities in zebrafish (50 to 200 μg/L); induces Parkinson’s disease-like neurodegeneration in rats (15 mg/kg twice weekly for 24 weeks)

Formal name: 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid, cyano(3-phenoxyphenyl)methyl ester

Synonyms: 

Molecular weight: 416.3

CAS: 52315-07-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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