An S1P2 agonist (EC50 = 0.78 μM in a reporter assay); selective for S1P2 over S1P1 and S1P3-5 in a TGFα-shedding assay (EC50s = 119

CYM 5478 – 5 mg

Brand:
Cayman
CAS:
870762-83-7
Storage:
-20
UN-No:
Non-Hazardous - /

CYM 5478 is a sphingosine-1-phosphate receptor 2 (S1P2) agonist (EC50 = 0.78 μM in a reporter assay).{52124} It is selective for S1P2 over S1P1 and S1P3-5 in a TGFα-shedding assay (EC50s = 119, 1,690, 1,950, >10,000, and >10,000 nM, respectively). CYM 5478 (0.1-10 μM) reduces serum starvation-induced decreases in C6 rat glioma cell viability. It also reduces accumulation of reactive oxygen species (ROS) and apoptosis induced by cisplatin (Item No. 13119) in C6 cells when used at a concentration of 10 μM.  

 

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SKU: 29024 - 5 mg Category:

Description

An S1P2 agonist (EC50 = 0.78 μM in a reporter assay); selective for S1P2 over S1P1 and S1P3-5 in a TGFα-shedding assay (EC50s = 119, 1,690, 1,950, >10,000, and >10,000 nM, respectively); reduces serum starvation-induced decreases in C6 rat glioma cell viability from 0.1-10 μM; reduces cisplatin-induced accumulation of ROS and apoptosis in C6 cells at 10 μM

Formal name: 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-5-(trifluoromethyl)-2(1H)-pyridinone

Synonyms: 

Molecular weight: 388.4

CAS: 870762-83-7

Purity: ≥98%

Formulation: A crystalline solid

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