A cyanobacterial toxin that targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 µM

Cylindrospermopsin – 50 µg

Brand:
Cayman
CAS:
143545-90-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 µM, respectively), leading to cell death.{14283} It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 µM.{14282} Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 µg/ml.{26087}  

 

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SKU: 10007867 - 50 µg Category:

Description

A cyanobacterial toxin that targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 µM, respectively), inhibits uridine monophosphate synthase complex activity (Ki = 10 µM), and induces DNA damage

Formal name: 6-[(R)-hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-2,4(1H,3H)-pyrimidinedione

Synonyms: 

Molecular weight: 415.4

CAS: 143545-90-8

Purity: ≥95%

Formulation: A powder

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Product Type|Biochemicals|Toxins||Research Area|Cancer|DNA Damage and Repair||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Environmental|Aquatic Systems

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