A bacterial cyclic dipeptide; activates a LuxR-based AHL E. coli biosensor and blocks activation of the biosensor by the quorum sensing signal molecule 3-oxo-C6-HSL (IC50 = 0.8 mM); reduces S. liquefaciens colony expansion by 21% at 15 μM; inhibits interaction of kinases Ras and Raf-1 in a yeast two-hybrid assay in a concentration-dependent manner

Cyclo(Δ-Ala-L-Val) – 1 mg

Brand:
Cayman
CAS:
25516-00-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclo(Δ-Ala-L-Val) is a bacterial cyclic dipeptide characterized as a diketopiperazine.{45034} It activates a LuxR-based N-acylhomoserine lactone (AHL) E. coli biosensor and blocks activation of the biosensor by the quorum sensing signal molecule N-(β-ketocaproyl)-L-homoserine lactone (3-oxo-C6-HSL; Item No. 10011207) with an IC50 value of 0.8 mM. Cyclo(Δ-Ala-L-Val) (15 μM) reduces S. liquefaciens colony expansion by 21%, indicating inhibition of swarming motility. It also inhibits the interaction of the kinases Ras and Raf-1 in a yeast two-hybrid assay in a concentration-dependent manner.{45035}  

 

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SKU: 25739 - 1 mg Category:

Description

A bacterial cyclic dipeptide; activates a LuxR-based AHL E. coli biosensor and blocks activation of the biosensor by the quorum sensing signal molecule 3-oxo-C6-HSL (IC50 = 0.8 mM); reduces S. liquefaciens colony expansion by 21% at 15 μM; inhibits interaction of kinases Ras and Raf-1 in a yeast two-hybrid assay in a concentration-dependent manner

Formal name: 3-methylene-6S-(1-methylethyl)-2,5-piperazinedione

Synonyms: 

Molecular weight: 168.2

CAS: 25516-00-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Peptides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Quorum Sensing

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