A cyclic neuropeptide and metabolite of TRH; ubiquitously expressed in the CNS

Cyclo(L-His-L-Pro) – 50 mg

Brand:
Cayman
CAS:
53109-32-3
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclo(L-His-L-Pro) is an endogenous cyclic neuropeptide and a metabolite of thyrotropin-releasing hormone (TRH).{57272} It is formed in the hypothalamus via the hydrolytic removal of pyroglutamic acid from TRH followed by non-enzymatic cyclization but is also synthesized de novo.{57273} It is ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood. Cyclo(L-His-L-Pro) (50 µM) reduces LPS-induced production of reactive oxygen species (ROS) and nitric oxide (NO), as well translocation of NF-κB in BV-2 microglia. Levels of cyclo(L-His-L-Pro) are increased in rat brain after six weeks of continuous ethanol consumption and cyclo(L-His-L-Pro) reduces ethanol-induced sleep time in rats when administered at a dose of 1 µmol/kg.{57272,57274} Cyclo(L-His-L-Pro) induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice, effects that can be partially reversed by the opioid antagonist naloxone.{57272}  

 

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SKU: 31172 - 50 mg Category:

Description

A cyclic neuropeptide and metabolite of TRH; ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood; reduces LPS-induced production of ROS and NO, as well as translocation of NF-κB in BV-2 microglia; levels are increased in rat brain after six weeks of continuous ethanol consumption; reduces ethanol-induced sleep time in rats at 1 µmol/kg; induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice

Formal name: (3S,8aS)-hexahydro-3-(1H-imidazol-4-ylmethyl)-pyrrolo[1,2-a]pyrazine-1,4-dione

Synonyms:  Cyclo(His-Pro)|Cyclo(histidyl-proline)|Histidylproline diketopiperazine|Histidylproline dioxopiperazine

Molecular weight: 234.3

CAS: 53109-32-3

Purity: ≥95%

Formulation: A neat oil

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