An inhibitor of protein synthesis in eukaryotes (IC50 = 5-50 μM) that functions by interfering with translational elongation; can either induce or inhibit apoptosis depending on cell type

Cycloheximide – 1 g

Brand:
Cayman
CAS:
66-81-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Cycloheximide is a glutarimide antibiotic produced by S. griseus that inhibits protein synthesis in eukaryotes (IC50 = 5-50 μM) by interfering with translational elongation.{23270} Its effects on protein synthesis can either induce or inhibit apoptosis depending on cell type.{23271} Cycloheximide is widely used as a tool in molecular biology research for ribosome profiling and translational profiling as well as to determine the half-life of a protein.{23273,23272}  

 

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Description

An inhibitor of protein synthesis in eukaryotes (IC50 = 5-50 μM) that functions by interfering with translational elongation; can either induce or inhibit apoptosis depending on cell type

Formal name: 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione

Synonyms:  Naramycin A|NSC 185

Molecular weight: 281.4

CAS: 66-81-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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