Description
A histamine H1 receptor antagonist; binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively); inhibits anti-IgE-induced histamine release from isolated human lung fragments (IC50 = 5.42 µM) but also induces histamine release (RC50 = 10.81 µM); reduces LPS-induced nitrite accumulation and protein levels of iNOS in RAW 264.7 cells at 100 nM; reduces immobility in the forced swim test in rats at 10 and 20 mg/kg
Formal name: 1-(diphenylmethyl)-4-methyl-piperazine, monohydrochloride
Synonyms:
Molecular weight: 302.8
CAS: 303-25-3
Purity: ≥98%
Formulation: A solid
