A second messenger that is biosynthesized from GTP by guanylate cyclases; activates protein kinase G (PKG) and modulates ion channel conductance

Cyclic GMP – 250 mg

Brand:
Cayman
CAS:
40732-48-7
Storage:
-20
UN-No:
Non-Hazardous - /

Guanosine 3′,5′-cyclic monophosphate (cyclic GMP or cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases. Activators of guanylate cyclases include nitric oxide and natriuretic peptides.{30357} cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis.{30357,30360,30359,30358} The degradation of cGMP to GMP is mediated by specific and non-specific phosphodiesterases.{22523,10616}  

 

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Description

A second messenger that is biosynthesized from GTP by guanylate cyclases; activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis

Formal name: cyclic 3′,​5′-​(hydrogen phosphate) guanosine, monosodium salt

Synonyms:  cGMP|Cyclic guanosine monophosphate|Guanosine 3’5′-cyclic monophosphate|Monosodium-GMP

Molecular weight: 367.2

CAS: 40732-48-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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