A potent Aurora kinase inhibitor (Kis = 8.0 and 9.2 nM for Aurora A and B kinases

CYC-116 – 1 mg

Brand:
Cayman
CAS:
693228-63-6
Storage:
-20
UN-No:
Non-Hazardous - /

CYC-116 is a potent Aurora kinase inhibitor exhibiting Ki values of 8.0 and 9.2 nM for Aurora kinases A and B, respectively.{33839} It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 exhibits broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC50 value of 0.54 µM (range = 0.09 – 1.6 µM). It is orally bioavailable and inhibits the growth of human tumor xenografts in mice.  

 

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Description

A potent Aurora kinase inhibitor (Kis = 8.0 and 9.2 nM for Aurora A and B kinases, respectively); selective over against a panel of CDKs and other kinases, with the exception of Flt-3 (Ki = 44 nM); exhibits broad-spectrum antiproliferative activity against a panel of human cancer cell lines (mean IC50 = 0.54 µM); orally bioavailable

Formal name: 4-(2-amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]-2-pyrimidinamine

Synonyms: 

Molecular weight: 368.5

CAS: 693228-63-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Aurora Signaling||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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