A CXCR3 antagonist; inhibits calcium mobilization induced by CXCL11 in HEK293 cells expressing the human receptor (IC50 = 0.06 µM); selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 µM; inhibits CXCR3-mediated migration of isolated human T cells (IC50 = ~100 nM)

CXCR3 Antagonist 6c – 1 mg

Brand:
Cayman
CAS:
870998-13-3
Storage:
-20
UN-No:
Non-Hazardous - /

CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).{52334} It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC50 = 0.06 µM). It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 µM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC50 = ~100 nM).  

 

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Description

A CXCR3 antagonist; inhibits calcium mobilization induced by CXCL11 in HEK293 cells expressing the human receptor (IC50 = 0.06 µM); selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 µM; inhibits CXCR3-mediated migration of isolated human T cells (IC50 = ~100 nM)

Formal name: 4-[2-[(3-chlorobenzoyl)amino]-4-[[[2-(2,4-dichlorophenyl)ethyl]amino]carbonyl]phenyl]-N-ethylhexahydro-1H-1,4-diazepine-1-carboxamide

Synonyms: 

Molecular weight: 617

CAS: 870998-13-3

Purity: ≥98%

Formulation: A crystalline solid

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