An AMPA receptor modulator; increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices; accelerates acquisition of a conditioned fear response in rats from 10-50 mg/kg; enhances performance in a spatial DNMS test in rats; reverses dominance between the initially dominant and submissive rat pairs in the rat reduction of submissive behavior model

CX-516 – 50 mg

Brand:
Cayman
CAS:
154235-83-3
Storage:
-20
UN-No:
Non-Hazardous - /

CX-516 is an AMPA receptor modulator.{39729,39730} It increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices. In vivo, CX-516 (10-50 mg/kg) accelerates acquisition of a conditioned fear response in rats in a dose-dependent manner.{39730} It enhances performance in a spatial, delayed nonmatch-to-sample (DNMS) test in rats.{39731} CX-516 also reverses dominance between initially dominant and submissive rat pairs, a marker of antidepressant-like activity, in the rat reduction of submissive behavior model.{39732}  

 

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Description

An AMPA receptor modulator; increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices; accelerates acquisition of a conditioned fear response in rats from 10-50 mg/kg; enhances performance in a spatial DNMS test in rats; reverses dominance between the initially dominant and submissive rat pairs in the rat reduction of submissive behavior model,

Formal name: 1-piperidinyl-6-quinoxalinyl-methanone

Synonyms:  Ampalex|BDP-12|Benzoyl-Piperidine-12,

Molecular weight: 241.3

CAS: 154235-83-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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