An inhibitor of αv integrins (IC50s = 1.8

CWHM12 – 1 mg

Brand:
Cayman
CAS:
1564286-55-0
Storage:
-20
UN-No:
Non-Hazardous - /

CWHM12 is an analog of RGD peptide (Item No. 14501), a tripeptide that inhibits integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation.{5588} CWHM12 selectively inhibits αv integrins (IC50s = 1.8, 0.8, 61, 1.5, and 0.2 nM for αvβ1, αvβ3, αvβ5, αvβ6, and αvβ8, respectively) over αIIbβ3, α2β1, and α10β1.{33437} CWHM 12 attenuates liver, lung, and pancreatic fibrosis in mice treated with CCl4 or cerulein.{33437,33439}  

 

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Description

An inhibitor of αv integrins (IC50s = 1.8, 0.8, 61, 1.5, and 0.2 nM for αvβ1, αvβ3, αvβ5, αvβ6, and αvβ8, respectively) over αIIbβ3, α2β1, and α10β1; attenuates liver, lung, and pancreatic fibrosis in mouse studies,

Formal name: (3S)-N-[3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino]benzoyl]glycyl-3-[3-bromo-5-(1,1-dimethylethyl)phenyl]-β-alanine

Synonyms: 

Molecular weight: 590.5

CAS: 1564286-55-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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