Description
An Hsp90 inhibitor; binds to Hspα and Hspβ (IC50s = 100 and 103 nM, respectively) and Hsp90 isolated from erlotinib-resistant NSCLC cells (IC50 = 70 nM); inhibits proliferation of 40 human cancer cell lines (IC50s = 0.04-0.9 µM); dose-dependently reduces tumor growth in a U87MG glioblastoma mouse xenograft model at 40-160 mg/kg; prolongs survival in a U87MG mouse orthotopic model at 160 mg/kg
Formal name: 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-1H-imidazo[4,5-c]pyridine-1-ethanamine
Synonyms:
Molecular weight: 442.6
CAS: 1061318-81-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer