A natural triterpene; reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro; inhibits growth of T24 bladder

Cucurbitacin E – 5 mg

Brand:
Cayman
CAS:
18444-66-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro.{38164} Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis.{38159,38160,38161} It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner.{38162} Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.{38163}  

 

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Description

A natural triterpene; reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro; inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis; increases bilirubin binding to HSA in human plasma in a dose-dependent manner; inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells,

Formal name: (9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione

Synonyms:  NSC 106399|NSC 521775

Molecular weight: 556.7

CAS: 18444-66-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Neuroscience

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