A plant-derived steroidal triterpene that induces cell cycle arrest or apoptosis in a range of cancer cell lines; inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM); suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice

Cucurbitacin B – 5 mg

Brand:
Cayman
CAS:
6199-67-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. It has diverse effects on mammalian cells, most notably inducing cell cycle arrest or apoptosis in a range of cancer cell lines.{23448,23449,30197} Cucurbitacin B inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM).{30195} It suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice.{30195} Cucurbitacin B blocks the inflammatory response of macrophages treated with lipopolysaccharide.{30196} In Drosophila, it serves as an ecdysteroid receptor antagonist (Kd = 5 µM).{30194}  

 

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Description

A plant-derived steroidal triterpene that induces cell cycle arrest or apoptosis in a range of cancer cell lines; inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM); suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice

Formal name: (2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione

Synonyms:  Cuc B|NSC 144154|NSC 49451

Molecular weight: 558.7

CAS: 6199-67-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Innate Immunity

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