An antagonist of TLR1/TLR2 (Ki = 0.41 µM); inhibits Pam3CSK4-induced NO production in RAW 264.7 cells (IC50 = 0.58 µM); selective for TLR1/TLR2 over TLR2/TLR6 and TLR3

CU CPT 22 – 5 mg

Brand:
Cayman
CAS:
1416324-85-0
Storage:
-20
UN-No:
Non-Hazardous - /

CU CPT 22 is an antagonist of toll-like receptor 1 (TLR1) and TLR2 heterodimers (TLR1/TLR2; Ki = 0.41 µM).{48799} It inhibits nitric oxide (NO) production induced by the TLR2 agonist Pam3CSK4 (Item No. 24126) in RAW 264.7 cells (IC50 = 0.58 µM). It is selective for TLR1/TLR2 over TLR2/TLR6 and TLR3, -4, and -7 homodimers, as well as 10 kinases at 0.5 µM. CU CPT 22 (8 µM) inhibits Pam3CSK4-induced release of TNF-α and IL-1β in RAW 264.7 cells by 60 and 95%, respectively.  

 

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Description

An antagonist of TLR1/TLR2 (Ki = 0.41 µM); inhibits Pam3CSK4-induced NO production in RAW 264.7 cells (IC50 = 0.58 µM); selective for TLR1/TLR2 over TLR2/TLR6 and TLR3, -4, and -7 homodimers, as well as 10 kinases at 0.5 µM; inhibits Pam3CSK4-induced release of TNF-α and IL-1β in RAW 264.7 cells at 8 µM

Formal name: 3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid, hexyl ester

Synonyms: 

Molecular weight: 362.4

CAS: 1416324-85-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition

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