A copper-containing compound with diverse biological activities; inhibits ferroptotic cell death induced by RSL3

Cu-ATSM – 25 mg

Brand:
Cayman
CAS:
68341-09-3
Storage:
-20
UN-No:
Non-Hazardous - /

Cu-ATSM is a copper-containing compound with diverse biological activities.{49720,30772,30772} It inhibits ferroptotic cell death induced by RSL3, erastin (Item No. 17754), or iron(II) (EC50s = 134, 169, and 171 nM, respectively), as well as RSL3-, erastin-, or iron-induced lipid peroxidation in N27 rat mesencephalic cells when used at a concentration of 1 µM.{49720} Cu-ATSM (30 mg/kg per day) increases mutant superoxide dismutase (SOD1G37R) protein levels, metalation, and activity in the spinal cord in the SOD1G37R transgenic mouse model of amyotrophic lateral sclerosis (ALS).{30772} It also increases the number of α-motor neurons and reduces oxidatively modified proteins in the spinal cord, as well as increases the latency to fall in the rotarod test in the same ALS mouse model. Cu-ATSM containing positron-emitting copper isotopes has been used in PET imaging applications for selective labeling of hypoxic tissue.{30773}  

 

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Description

A copper-containing compound with diverse biological activities; inhibits ferroptotic cell death induced by RSL3, erastin, or iron(II) (EC50s = 134, 169, and 171 nM, respectively), as well as RSL3-, erastin-, or iron-induced lipid peroxidation in N27 rat mesencephalic cells at 1 µM; increases SOD1G37R protein levels, metalation, and activity in the spinal cord in the SOD1G37R transgenic mouse model of ALS at 30 mg/kg per day; increases the number of α-motor neurons and reduces oxidatively modified proteins in the spinal cord, as well as increases the latency to fall in the rotarod test in the same ALS mouse model; versions containing positron-emitting copper isotopes have been used in PET imaging applications for selective labeling of hypoxic tissue

Formal name: (SP-4-2)-[[2,2′-(1,2-dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato-κN2,κS]](2-)]-copper

Synonyms:  copper-ATSM|CuII(atsm)

Molecular weight: 321.9

CAS: 68341-09-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Neuroscience|Neurodegenerative Disorders||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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