Description
A copper-containing compound with diverse biological activities; inhibits ferroptotic cell death induced by RSL3, erastin, or iron(II) (EC50s = 134, 169, and 171 nM, respectively), as well as RSL3-, erastin-, or iron-induced lipid peroxidation in N27 rat mesencephalic cells at 1 µM; increases SOD1G37R protein levels, metalation, and activity in the spinal cord in the SOD1G37R transgenic mouse model of ALS at 30 mg/kg per day; increases the number of α-motor neurons and reduces oxidatively modified proteins in the spinal cord, as well as increases the latency to fall in the rotarod test in the same ALS mouse model; versions containing positron-emitting copper isotopes have been used in PET imaging applications for selective labeling of hypoxic tissue
Formal name: (SP-4-2)-[[2,2′-(1,2-dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato-κN2,κS]](2-)]-copper
Synonyms: copper-ATSM|CuII(atsm)
Molecular weight: 321.9
CAS: 68341-09-3
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Neuroscience|Neurodegenerative Disorders||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase
