A natural quinoid diterpene that

Cryptotanshinone – 25 mg

Brand:
Cayman
CAS:
35825-57-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions.{28060} Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in C2C12 myotubes and activates p38 MAPK in DU145 cells.{28058,28059} It inhibits the protein tyrosine phosphatase SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells.{28057,28056} Cryptotanshinone has a variety of anti-cancer actions, including inhibition of cell proliferation, induction of apoptosis, and reduction in angiogenesis.{28060,28056,28055} However, it is poorly absorbed and has low bioavailability in vivo.{28055}  

 

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Description

A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells; inhibits SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells; has a variety of anti-cancer actions

Formal name: (1R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro[1,2-b]furan-10,11-dione

Synonyms: 

Molecular weight: 296.4

CAS: 35825-57-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Activators|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p38 MAPK Signaling||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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