An alkaloid with anti-inflammatory activity; inhibits prostaglandin synthetase (IC50 = 424 μM); reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis at 100 mg/kg per day

Cryogenine – 5 mg

Brand:
Cayman
CAS:
10308-13-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.{43275} It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.{46526}  

 

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SKU: 25287 - 5 mg Category:

Description

An alkaloid with anti-inflammatory activity; inhibits prostaglandin synthetase (IC50 = 424 μM); reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis at 100 mg/kg per day, p.o.

Formal name: (4aR,6S,9Z,20S)-2,3,4,4a,5,6-hexahydro-14-hydroxy-17,18-dimethoxy-20H-6,20-methano-11,15-metheno-1H,8H-benzo[g]pyrido[2,1-d][1,5]oxaazacyclohexadecin-8-one

Synonyms:  NSC 272693

Molecular weight: 435.5

CAS: 10308-13-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Prostaglandin Synthases||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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