Description
Prostaglandin D2 (PGD2) elicits its biological function through interaction with two distinct G protein-coupled receptors, DP1 and CRTH2/DP2. CRTH2 primarily couples to Gi or Gq subunits to mobilize Ca2+, induce cell migration, and up-regulate adhesion molecules.{11493} CRTH2 mRNA has been detected in various tissues including liver, lung, kidney, brain, heart, thymus, and spleen and in various cell lineages including both hematopoietic and non-hematopoietic cell lines.{9767} Human CRTH2 is 395 amino acids in length with an estimated molecular weight of 43 kDa. Cayman’s CRTH2/DP2 Receptor (N-Term) Polyclonal Antibody can be used for western blot of CRTH2 on samples of human, mouse, and rat origin. It detects both unglycosylated and glycosylated protein at sizes ranging from 35-40 to 50-70 kDa, as reported by Nagata et al., in 1999.{9770}
Synonyms: Chemoattractant-receptor Homologous Molecule Expressed on Th2 Cells|DP2 Receptor|GPR44|Prostaglandin D2 Receptor 2
Immunogen: CRTH2/DP2 protein amino acids 2-21
Formulation: Peptide affinity-purified IgG, lyophilized from TBS, pH 7.4
Isotype:
Applications: ICC and WB
Origin: Animal/Rabbit
Stability: 730 days
Application|Immunocytochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
