A guanosine analog with diverse biological activities; cytotoxic to P338

Crotonoside – 1 mg

Brand:
Cayman
CAS:
1818-71-9
Storage:
-20
UN-No:
Non-Hazardous - /

Crotonoside is a guanosine analog originally isolated from C. tiglium that has diverse biological activities.{47658,47659,47660} It is cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively).{47658} Crotonoside (48 mg/kg per day for 12 days) reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models. It has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells.{47661} Crotonoside decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively) and reduces carotid blood pressure in anesthetized cats when administered intravenously at a dose of 0.5 μmol/kg.{47659,47660}  

 

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Description

A guanosine analog with diverse biological activities; cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively); reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models at 48 mg/kg per day for 12 days; has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells; decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively); reduces carotid blood pressure in anesthetized cats at 0.5 μmol/kg

Formal name: 2,3-dihydro-2-oxo-adenosine

Synonyms:  2-Hydroxyadenosine|Isoguanine riboside|Isoguanosine|NSC 12161

Molecular weight: 283.2

CAS: 1818-71-9

Purity: ≥95%

Formulation: A crystalline solid

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