An inducer of type I interferon production; induces IRF3 phosphorylation

Cridanimod (sodium salt) – 1 mg

Brand:
Cayman
CAS:
58880-43-6
Storage:
-20
UN-No:
Non-Hazardous - /

Cridanimod is an inducer of type I interferon (IFN) production.{35839,50314} It induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in stimulator of interferon genes (STING) mutant, murine macrophages.{35839} In vivo, cridanimod (112-1,792 mg/kg) increases plasma levels of IFN in weanling and adult mice.{50314} Cridanimod inhibits viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses with protective doses (PD50s) ranging from 17-320 mg/kg.{48488} It increases uterine expression of estrogen and progesterone receptors in ovariectomized rats.{48489} Cridanimod also reverses tamoxifen-induced decreases in progesterone receptor expression in young rats.  

 

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SKU: 27884 - 1 mg Category:

Description

An inducer of type I interferon production; induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in STING mutant, murine macrophages; increases plasma levels of IFN in weanling and adult mice from 112-1,792 mg/kg; protects against viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses (PD50s = 17-320 mg/kg); increases uterine expression of estrogen and progesterone receptors in ovariectomized rats; reverses tamoxifen-induced decreases in progesterone receptor expression in young rats

Formal name: 9-oxo-10(9H)-acridineacetic acid, monosodium salt

Synonyms:  10-Carboxymethyl-9-Acridanone

Molecular weight: 275.2

CAS: 58880-43-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease|Viral Diseases|HSV

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