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CREB (Phospho-Ser133) Polyclonal Antibody – 1 ea

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Cayman
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It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus.{14339} The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors.{14341} This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory.{14342,14343} A variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 is required for CREB-mediated transcription.{14338,14340}  

 

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SKU: 10009181 - 1 ea Category:

Description

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser133 of rat CREB · Host: rabbit · Cross-reactivity: (+) rat CREB · Application: WB • CREB is one of the best characterized stimulus-induced transcription factors. This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory. A variety of protein kinases including PKA, MAPKs, and CaMKs phosphorylate CREB at Ser133, which is required for CREB-mediated transcription.

Synonyms:

Immunogen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser133 of rat CREB

Formulation: Affinity-purified IgG

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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