Description
A benzamide; inhibits phosphorylation of p38 MAPK in IL-1β-stimulated primary rat astrocytes by 70 to 80% at 10-300 nM; decreases TNF-α-induced apoptosis in the corpus callosum and septum, but not in the neocortex or basal ganglia, as well as reduces TNF-α-induced decreases in GFAP levels in isolated rat brain slices at 20 mg/kg per day; decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, induced by TNF-α in a rat model of AIDS dementia at 20 mg/kg per day; reduces crypt loss and decreases the number of ulcers and inflammatory cells in colonic lesions in mouse models of colitis induced by TNBS or DSS at 30 mg/kg per day
Formal name: 4-(acetylamino)-N-(1,1-dimethylethyl)-benzamide
Synonyms:
Molecular weight: 234.3
CAS: 183619-38-7
Purity: ≥98%
Formulation: A solid
