A 5-HT1B agonist (Ki = 2 nM in a radioligand binding assay); selective for 5-HT1B over 5-HT1A

CP 94,253 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
845861-39-4
Storage:
-20
UN-No:
Non-Hazardous - /

CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay).{48735} It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg.{48736} It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg.{48737} CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.{48738}  

 

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Description

A 5-HT1B agonist (Ki = 2 nM in a radioligand binding assay); selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively); reduces aggressive behavior in a resident-intruder test in mice at 10 and 17 mg/kg; decreases alcohol-induced aggression in mice (ED50 = 3.8 mg/kg); decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, 5 mg/kg; increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats at 2.5 mg/kg

Formal name: 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine, monohydrochloride

Synonyms: 

Molecular weight: 293.8

CAS: 845861-39-4

Purity: ≥98%

Formulation: A crystalline solid

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