A PPARα agonist; binds selectively to PPARα (Ki = 24.5 nM) over PPARβ and PPARγ (Kis = >10

CP 775,146 – 10 mg

Brand:
Cayman
CAS:
702680-17-9
Storage:
-20
UN-No:
Non-Hazardous - /

CP 775,146 is an agonist of peroxisome proliferator-activated receptor α (PPARα) that selectively binds to PPARα (Ki = 24.5 nM) over PPARβ and PPARγ (Kis = >10,000 nM).{51044} CP 775,146 induces PPARα transcriptional activity in a reporter assay (EC50s = 57 and 284 nM for human and rat receptors, respectively, expressed in HepG2 cells). It decreases plasma triglyceride levels in mice by 73% when administered at a dose of 2 mg/kg per day for two days.  

 

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SKU: 28290 - 10 mg Category:

Description

A PPARα agonist; binds selectively to PPARα (Ki = 24.5 nM) over PPARβ and PPARγ (Kis = >10,000 nM); induces PPARα transcriptional activity in a reporter assay (EC50s = 57 and 284 nM for human and rat receptors, respectively, expressed in HepG2 cells); decreases plasma triglyceride levels in mice by 73% at 2 mg/kg per day for two days

Formal name: 2-methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoic acid

Synonyms: 

Molecular weight: 423.5

CAS: 702680-17-9

Purity: ≥95%

Formulation: A solid

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