A selective inhibitor of PDGFRβ and PDGFRα kinases (IC50s = 1 and 10 nM

CP 673,451 – 10 mg

Brand:
Cayman
CAS:
343787-29-1
Storage:
-20
UN-No:
Non-Hazardous - /

CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor β (PDGFRβ) kinase with an IC50 value of 1 nM.{30922} It also inhibits the PDGFRα kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2.{30922} In several in vivo tumor models, CP-673,451 has antiangiogenic and antitumor activity.{30922,30923,30921}  

 

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Description

A selective inhibitor of PDGFRβ and PDGFRα kinases (IC50s = 1 and 10 nM, respectively); antiangiogenic and antitumor activity in several in vivo tumor models

Formal name: 1-[2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine

Synonyms: 

Molecular weight: 417.5

CAS: 343787-29-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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