An ACC inhibitor (IC50s = 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2

CP 640,186 – 25 mg

Brand:
Cayman
CAS:
591778-68-6
Storage:
-20
UN-No:
Non-Hazardous - /

Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.{31019} It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.{31019} CP 640,186 can also stimulate muscle fatty acid oxidation (EC50 = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED50 = ~30 mg/kg).{31019}  

 

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Description

An ACC inhibitor (IC50s = 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively); lowers malonyl-CoA levels and inhibits hepatic fatty acid and triglyceride synthesis both in vitro and in vivo

Formal name: [(3R)​-​1′-​(9-​anthracenylcarbonyl)​[1,​4′-​bipiperidin]​-​3-​yl]​-​4-​morpholinyl-methanone

Synonyms: 

Molecular weight: 485.6

CAS: 591778-68-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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