A potent EP2 receptor agonist (IC50s = 10 and 15 nM for human and rat EP2

CP 544,326 – 1 mg

Brand:
Cayman
CAS:
752187-80-7
Storage:
-20
UN-No:
Non-Hazardous - /

CP 544,326 is a potent agonist of E prostanoid (EP) receptor 2 (IC50s = 10 and 15 nM for human and rat EP2, respectively).{38442} It is selective for EP2 over other EP receptors (IC50s = >3,200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors (≤30% inhibition at a concentration of 10 μM). CP 544,326 increases cAMP levels in HEK293 cells expressing human EP2 (EC50 = 2.8 nM). CP 544,326 has poor corneal permeability in an ex vivo rabbit corneal model. However, PF-04217329, a cell-permeable prodrug form of CP 544,326, reduces intraocular pressure in rabbit, canine, and marmoset models of glaucoma.  

 

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SKU: 22945 - 1 mg Category:

Description

A potent EP2 receptor agonist (IC50s = 10 and 15 nM for human and rat EP2, respectively); selective for EP2 over other EP receptors (IC50s = >3,200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors (≤30% inhibition at a concentration of 10 μM); increases cAMP in HEK293 cells expressing human EP2 (EC50 = 2.8 nM) ,

Formal name: 2-[3-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-acetic acid

Synonyms: 

Molecular weight: 478.5

CAS: 752187-80-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience

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