COX-1 and COX-2 catalyze the production of the prostaglandin (PG), thromboxane, and prostacyclin precursor PGH2. COX-2 is responsible for the biosynthesis of PGs under acute inflammatory conditions. This inducible COX-2 is believed to be the target enzyme for the anti-inflammatory activity of nonsteroidal anti-inflammatory drugs. The COX-2 (ovine) Inhibitor Screening Assay directly measures PGF2α (Item No. 16010) by SnCl2 reduction of COX-2-derived PGH2 (Item No. 17020) produced in the COX-2 reaction. The prostanoid product is quantified via enzyme immunoassay (EIA) using a broadly specific antiserum that binds to all the major PG compounds. This assay includes ovine COX-2 allowing the user to screen specific inhibitors. This assay is an excellent tool that can be used for general inhibitor screening, or to eliminate false positive leads generated by less specific methods.
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Origin: Animal/Rabbit|Animal/Bovine|Animal/Sheep
Product Type|Assay Kits|Colorimetric Assays||Product Type|Assay Kits|Inhibitor Screening Assays||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
For the quantitation of Mouse Ifng concentrations in bone tissue, cell culture supernates and serum.
Available on backorder
For quantitative detection of rat BMPER in cell culture supernates, serum and plasma (heparin, EDTA, citrate).
Available on backorder
For quantitative detection of human BMPER in cell culture supernates, serum and plasma (heparin, EDTA, citrate).
Available on backorder
