A mixture of the antibiotics sulfamethoxazole and trimethoprim; bactericidal against 12 patient-derived community-acquired MRSA strains at 0.05 mg/L; prevents lung and spleen bacterial colonization in a mouse model of inhaled B. mallei infection at 240 mg/kg; resolves cutaneous tail lesions in a mouse model of S. xylosus infection

Cotrimoxazole – 250 mg

Brand:
Cayman
CAS:
8064-90-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cotrimoxazole is a mixture of the antibiotics sulfamethoxazole (Item No. 23613) and trimethoprim (Item No. 16473).{54278,54279} It is bactericidal against 12 patient-derived community-acquired methicillin-resistant S. aureus (MRSA) strains when used at a concentration of 0.05 mg/L.{54279} Cotrimoxazole (240 mg/kg) prevents lung and spleen bacterial colonization in a mouse model of inhaled B. mallei infection, but does not eradicate infection when administered post B. mallei exposure in the same model.{54280} It also resolves cutaneous tail lesions in a mouse model of S. xylosus infection.{54281} Formulations containing cotrimoxazole have been used in the treatment of MRSA infections and the prevention of glanders disease in human and veterinary medicine, respectively.  

 

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SKU: 30781 - 250 mg Category:

Description

A mixture of the antibiotics sulfamethoxazole and trimethoprim; bactericidal against 12 patient-derived community-acquired MRSA strains at 0.05 mg/L; prevents lung and spleen bacterial colonization in a mouse model of inhaled B. mallei infection at 240 mg/kg; resolves cutaneous tail lesions in a mouse model of S. xylosus infection

Formal name: 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine mixture with 4-amino-N-(5-methyl-3-isoxazolyl)-benzenesulfonamide

Synonyms:  TMP-SMX|Trimethoprim-Sulfamethoxazole

Molecular weight: 543.6

CAS: 8064-90-2

Purity: ≥98%

Formulation: A solid

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