A major metabolite of nicotine that is often used as a biomarker to detect tobacco use; binds nicotinic- and muscarinic-type acetylcholine receptors and demonstrates antipsychotic drug-like properties and neuroprotective properties

(-)-Cotinine – 250 mg

Brand:
Cayman
CAS:
486-56-6
Storage:
-20
UN-No:
Non-Hazardous - /

Cotinine is a minor alkaloid found in tobacco plants and is a major metabolite of nicotine.{20194} It has a long pharmacological half-life (15-19 hours) compared to that of nicotine (2-3 hours) and is often used as a biomarker to detect tobacco use.{24960,20195,20196} Cotinine binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.{24960}  

 

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Description

A major metabolite of nicotine that is often used as a biomarker to detect tobacco use; binds nicotinic- and muscarinic-type acetylcholine receptors and demonstrates antipsychotic drug-like properties and neuroprotective properties

Formal name: 1-methyl-5S-(3-pyridinyl)-2-pyrrolidinone

Synonyms:  NIH 10498

Molecular weight: 176.2

CAS: 486-56-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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