An indole alkaloid; increases levels of LC3-II in Neuro2a and SH-SY5Y neuronal cells at 6.25-25 µM; increases degradation of wild-type and A53T mutant α-synuclein in PC12 cells at 25 µM; reduces methamphetamine-induced increases in locomotor activity in rats at 30 and 100 mg/kg

Corynoxine – 5 mg

Brand:
Cayman
CAS:
6877-32-3
Storage:
-20
UN-No:
- 2811 / 6.1

Corynoxine is an indole alkaloid that has been found in U. macrophylla and has neuroprotective activity.{45601,45602} It increases levels of the autophagy marker LC3-II in Neuro2a and SH-SY5Y neuronal cells when used at concentrations ranging from 6.25 to 25 µM.{45601} Corynoxine (25 µM) increases degradation of wild-type and A53T mutant α-synuclein, a major component of Lewy bodies in the brain of Parkinson’s disease patients, in PC12 cells, an effect that can be reversed by the autophagy inhibitors 3-methyladenine (Item No. 13242) and chloroquine (Item No. 14194). It reduces increases in methamphetamine-induced locomotor activity in rats when administered at doses of 30 and 100 mg/kg.{45602}  

 

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SKU: 28496 - 5 mg Category:

Description

An indole alkaloid; increases levels of LC3-II in Neuro2a and SH-SY5Y neuronal cells at 6.25-25 µM; increases degradation of wild-type and A53T mutant α-synuclein in PC12 cells at 25 µM; reduces methamphetamine-induced increases in locomotor activity in rats at 30 and 100 mg/kg

Formal name: (αE,1′S,6′S,7′S,8′aS)-6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, methyl ester

Synonyms: 

Molecular weight: 384.5

CAS: 6877-32-3

Purity: ≥98%

Formulation: A crystalline solid

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