Description
An alkaloid with diverse biological activities; inhibits LPS-induced production of NO in primary rat microglia (IC50 = 15.7 µM); inhibits PDGF-BB-induced ERK1/2 activation in, and proliferation of, rat aortic VSMCs from 5-50 µM; inhibits compound 48/80-induced histamine release from LAD 2 mast cells from 25-200 µM; reduces compound 48/80-induced local anaphylaxis and mast cell degranulation in mouse hind paws at 0.5, 2.5, and 5 mg/kg; reduces methamphetamine-induced hyperlocomotion in mice at 30 and 100 mg/kg
Formal name: (αE,1′R,6′R,7′S,8′aS)-6′-ethenyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, methyl ester
Synonyms: δ18-Rynchophylline
Molecular weight: 382.5
CAS: 630-94-4
Purity: ≥98%
Formulation: A solid
