Cortistatin-29 (rat) (trifluoroacetate salt) – 500 µg

Brand:
Cayman
CAS:
1815618-17-7
Storage:
-20
UN-No:
Non-Hazardous - /

Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28.{38846} It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex.{38846,38847} Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-5, respectively.{38847} Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence.  

 

Available on backorder

SKU: 24740 - 500 µg Category:

Description

A neuropeptide; structurally similar to somatostatin-28; expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex; binds to SST receptors (IC50s = 2.8, 7.1, 0.2, 3, and 13.7 nm for SST1-5, respectively); found at similar levels as cortistatin-14 in mouse AtT20 cells but secreted at a lower level


Formal name: 5-oxo-L-prolyl-L-α-glutamyl-L-arginyl-L-prolyl-L-prolyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-prolyl-L-histidyl-L-arginyl-L-α-aspartyl-L-lysyl-L-lysyl-L-prolyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-seryl-L-seryl-L-cysteinyl-L-lysine, cyclic (17→28)-disulfide, trifluoroacetate salt

Synonyms: 

Molecular weight: 3,540.00

CAS: 1815618-17-7

Purity: ≥95%

Formulation: A lyophilized powder


Product Type|Biochemicals|Peptides|Neuropeptides||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Neuroscience