A synthetic glucocorticoid with anti-inflammatory properties; decreases the size of BCG vaccine-induced dermal lesions and tuberculin reactions in rabbits (2 mg/kg on alternate days over the course of 46 days); slows tissue regeneration in a rabbit model of wound healing (2.5 mg/kg per day

Cortisone Acetate – 25 g

Brand:
Cayman
CAS:
50-04-4
Storage:
-20
UN-No:
Non-Hazardous - /

Cortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties.{40677} It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing.{40678} It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%.{40679} Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.  

 

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SKU: 23798 - 25 g Category:

Description

A synthetic glucocorticoid with anti-inflammatory properties; decreases the size of BCG vaccine-induced dermal lesions and tuberculin reactions in rabbits (2 mg/kg on alternate days over the course of 46 days); slows tissue regeneration in a rabbit model of wound healing (2.5 mg/kg per day, s.c., over 4 weeks); decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%

Formal name: 21-(acetyloxy)-17-hydroxy-pregn-4-ene-3,11,20-trione

Synonyms:  Cortisone 21-acetate|NSC 49420

Molecular weight: 402.5

CAS: 50-04-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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