Description
A triterpenoid with diverse biological activities; cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively); inhibits TPA-induced ear edema in mice (ID50 = 0.09 mg/ear); reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes at 2 and 10 mg/kg; reduces systolic blood pressure and serum levels of free fatty acids, TBARS, 8-OHdG, 3-nitrotyrosine, and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome at 0.072% in the diet
Formal name: 2α,3β-dihydroxy-urs-12-en-28-oic acid
Synonyms: 2α-Hydroxyursolic Acid|Glucosol
Molecular weight: 472.7
CAS: 4547-24-4
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Metabolic Syndrome||Research Area|Immunology & Inflammation||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation
