An isoquinoline alkaloid; scavenges ROS in isolated kidney mitochondria in a DCFH-DA assay (IC50 = 48.93 μM); inhibits AChE and BChE but not BACE1 in cell-free enzyme assays (IC50s = 0.8

Coptisine (chloride) – 100 mg

Brand:
Cayman
CAS:
6020-18-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Coptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has diverse biological activities, including antioxidant, enzyme inhibitory, antiproliferative, and anti‑hypercholesterolemic properties.{47685,52041,47686,50112,50111} It inhibits the production of reactive oxygen species (ROS) in isolated kidney mitochondria in a 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA; Item No. 85155) assay (IC50 = 48.93 μM).{47685} Coptisine inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) but not β-secretase 1 (BACE1) in cell-free enzyme assays (IC50s = 0.8, 5.81, and >100 μM, respectively). It also inhibits indoleamine 2,3-dioxygenase (IDO) in vitro (IC50 = 6.3 μM), as well as organic cation transporter 1 (OCT1), OCT2, and OCT3 in MDCK cells (IC50s = 0.931, 2.27, and 2.27 μM, respectively, for the human transporters).{52041,47686} It inhibits proliferation of A549, H460, and H2170 human lung cancer cells with IC50 values of 18.09, 29.5, and 21.6 μM, respectively.{50112} Coptisine (70.05 mg/kg) decreases total serum cholesterol, triglyceride, and LDL-cholesterol levels and increases serum HDL-cholesterol levels in Syrian golden hamsters fed a high-fat and high-cholesterol diet.{50111}  

 

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Description

An isoquinoline alkaloid; scavenges ROS in isolated kidney mitochondria in a DCFH-DA assay (IC50 = 48.93 μM); inhibits AChE and BChE but not BACE1 in cell-free enzyme assays (IC50s = 0.8, 5.81, and >100 μM, respectively); inhibits IDO in vitro (IC50 = 6.3 μM); inhibits OCT1, OCT2, and OCT3 in MDCK cells (IC50s = 0.931, 2.27, and 2.27 μM, respectively, for the human transporters); inhibits proliferation of A549, H460, and H2170 human lung cancer cells (IC50s = 18.09, 29.5, and 21.6 μM, respectively); decreases total serum cholesterol, triglyceride, and LDL-cholesterol levels and increases serum HDL-cholesterol levels in Syrian golden hamsters fed a high-fat and high-cholesterol diet at 70.05 mg/kg

Formal name: 6,7-dihydro-bis[1,3]benzodioxolo[5,6-a:4′,5′-g]quinolizinium, monochloride

Synonyms: 

Molecular weight: 355.8

CAS: 6020-18-4

Purity: ≥98%

Formulation: A solid

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