A monolignol; a precursor in the biosynthesis of lignin; has been used in the synthesis of lignin and a variety of phytochemicals; an inhibitor of SAAH in vitro (IC50 = 34 nM); increases protein levels of Hsf1

Coniferyl Alcohol – 250 mg

Brand:
Cayman
CAS:
458-35-5
Storage:
-20
UN-No:
Non-Hazardous - /

Coniferyl alcohol is a monolignol that has been found in pine sap.{53176} It is a precursor in the biosynthesis of lignin and has been used in the synthesis of lignin and a variety of phytochemicals.{53172,53173} Coniferyl alcohol is an inhibitor of S-adenosyl-homocysteine hydrolase (SAAH) in vitro (IC50 = 34 nM).{53174} It increases the promoter activity of Hsp25 and Hsp70 in NCI H460 cells, as well as protein levels of Hsf1, Hsp27, and Hsp70 in L132 human lung fibroblast cells when used at a concentration of 3 µM.{53175} It also prevents cell death of Hsf1+/+, but not Hsf1-/-, mouse embryonic fibroblasts induced by paclitaxel (Item No. 10461), cisplatin (Item No. 13119), or ionizing radiation (IR), and inhibits IR-induced bone marrow damage in mice when administered at a dose of 10 mg/kg.  

 

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SKU: 29470 - 250 mg Category:

Description

A monolignol; a precursor in the biosynthesis of lignin; has been used in the synthesis of lignin and a variety of phytochemicals; an inhibitor of SAAH in vitro (IC50 = 34 nM); increases protein levels of Hsf1, Hsp27, and Hsp70 in L132 human lung fibroblast cells at 3 µM; prevents cell death of Hsf1+/+, but not Hsf1-/-, mouse embryonic fibroblasts induced by paclitaxel, cisplatin, or IR; inhibits IR-induced bone marrow damage in mice at 10 mg/kg

Formal name: 4-(3-hydroxy-1-propen-1-yl)-2-methoxy-phenol

Synonyms:  Coniferol

Molecular weight: 180.2

CAS: 458-35-5

Purity: ≥98%

Formulation: A solid

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