Blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50s = 2.1-2.3 μM); blocks cell surface expression of viral glycoproteins without affecting their synthesis and

Concanamycin A – 1 mg

Brand:
Cayman
CAS:
80890-47-7
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Concanamycin A is a plecomacrolide antibiotic produced by Streptomyces that blocks lysosomal acidification through selective inhibition of the vacuolar H+-ATPase (V-ATPase; EC50s = 2.1-2.3 μM).{20777,20781,20778} Concanamycin A blocks cell surface expression of viral glycoproteins without affecting their synthesis and, at 0.8 μM, prevents entry of influenza virus into cells.{20779}  

 

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SKU: 11050 - 1 mg Category:

Description

Blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50s = 2.1-2.3 μM); blocks cell surface expression of viral glycoproteins without affecting their synthesis and, at 0.8 μM, prevents entry of influenza virus into cells

Formal name: (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propen-1-yl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyl-oxacyclooctadeca-3,5,13,15-tetraen-2-one

Synonyms:  Antibiotic X 4357B|NSC 674620|X 4357B

Molecular weight: 866.1

CAS: 80890-47-7

Purity: ≥95%

Formulation: A solution in acetonitrile

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Infectious Disease|Viral Diseases|Influenza

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