A mast cell degranulator; a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde; supresses CaM (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C (IC50s = 2.1 and 5.0 μg/ml for cytosolic and particulate phosphatidylinositol-specific activities

Compound 48/80 (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
848035-21-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells.{36028} Compound 48/80 also inhibits human platelet aggregation through suppression of calmodulin (CaM) (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C (IC50s = 2.1 and 5.0 μg/ml for cytosolic and particulate phosphatidylinositol-specific activities, respectively).{36029,36030}  

 

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Description

A mast cell degranulator; a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde; supresses CaM (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C (IC50s = 2.1 and 5.0 μg/ml for cytosolic and particulate phosphatidylinositol-specific activities, respectively) ,

Formal name: 4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-benzeneethanamine, trihydrochloride

Synonyms: 

Molecular weight: 629.1

CAS: 848035-21-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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