An inhibitor of microtubule assembly (ID50 = 2 µM) with anticancer properties; inhibits proliferation of hepatocellular carcinoma (IC50s = 9.2-728.2 nM) and other carcinoma cell lines (IC50s = 12.2-2

Combretastatin A1 – 50 mg

Brand:
Cayman
CAS:
109971-63-3
Storage:
-20
UN-No:
Non-Hazardous - /

Combretastatin A1 is a cis-stilbene originally isolated from C. caffrum that inhibits microtubule assembly (ID50 = 2 µM) by binding to the colchicine (Item No. 9000760) binding site on β-tubulin.{38547,38548} It inhibits proliferation of hepatocellular carcinoma (IC50s = 9.2-728.2 nM) and other carcinoma cell lines (IC50s = 12.2-2,247 nM).{38548} Combretastatin A1 increases apoptosis of HepG2 cells in a GSK3β-dependent manner by decreasing the levels of MCL-1 and β-catenin. It inhibits tumor growth in a hepatocellular carcinoma mouse xenograft model when administered at doses of 2 or 4 mg/kg for 4 weeks. It also enhances the effects of carboplatin (Item No. 13112), paclitaxel (Item No. 10461), and cisplatin (Item No. 13119) in murine models of cancer.{38549,38550} Combretastatin A1 decreases functional vascular volume within hours in a well-vascularized murine colon adenocarcinoma model.{38551}  

 

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Description

An inhibitor of microtubule assembly (ID50 = 2 µM) with anticancer properties; inhibits proliferation of hepatocellular carcinoma (IC50s = 9.2-728.2 nM) and other carcinoma cell lines (IC50s = 12.2-2,247 nM); inhibits tumor growth in a hepatocellular carcinoma mouse xenograft model when administered at doses of 2 or 4 mg/kg for 4 weeks; decreases functional vascular volume within hours in a well-vascularized murine colon adenocarcinoma model

Formal name: 3-methoxy-6-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-1,2-benzenediol

Synonyms:  CA1

Molecular weight: 332.4

CAS: 109971-63-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Natural Products|Stilbenes||Research Area|Cancer|Cell Death|Apoptosis

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