Description
A diterpenoid furanolactone with diverse biological activities; inhibits the growth of T. brucei in vitro and induces complete parasite clearance in T. brucei-infected mice (25 mg/kg per day for 3 days); selectively inhibits COX-2 over COX-1 (EC50s = 53.1 and 327 μM, respectively); reduces carrageenan-induced paw edema in rats; reduces the number of lesions in a rat model of azoxymethane-induced colon carcinogenesis (4, 20, and 100 ppm, dietary); reduces urethane and reduces sleeping time induced by a mixture of urethane and α-choralose but prolongs hexobarbital-induced sleeping time in mice,
Formal name: 9-(3-furanyl)-1R,4R,4aR,5,6,6aR,9S,10,10aS,10bS-decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c’]dipyran-3,7-dione
Synonyms:
Molecular weight: 358.4
CAS: 546-97-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Cancer||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms
