A coumarin with diverse biological activities; inhibits depolarization-induced calcium uptake in GH3 rat pituitary cells; inhibits HIV-1 replication in H9 cells (EC50 = 4.6 µM); inhibits IL-1β-induced production of IL-6 in A549 cells and reduces iNOS levels and LPS-induced NO production in MH-S cells; decreases the number of alveolar and interstitial macrophages and alveolar wall thickness in a mouse model of LPS-induced lung inflammation from 20-60 mg/kg; reduces formalin-induced paw licking in mice at 10 mg/kg

Columbianadin – 10 mg

Brand:
Cayman
CAS:
5058-13-9
Storage:
-20
UN-No:
Non-Hazardous - /

Columbianadin is a coumarin that has been found in A. pubescens and has diverse biological activities.{53159,53160,53161,53162} It inhibits depolarization-induced calcium uptake in GH3 rat pituitary cells.{53159} Columbianadin inhibits HIV-1 replication in H9 cells (EC50 = 4.6 µM).{53160} It inhibits IL-1β-induced production of IL-6 in A549 cells and reduces inducible nitric oxide synthase (iNOS) levels and LPS-induced NO production in MH-S cells.{53161} Columbianadin (20-60 mg/kg) decreases the number of alveolar and interstitial macrophages and alveolar wall thickness in a mouse model of LPS-induced lung inflammation. It also reduces formalin-induced paw licking in mice when administered at a dose of 10 mg/kg.{53162}  

 

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SKU: 27661 - 10 mg Category:

Description

A coumarin with diverse biological activities; inhibits depolarization-induced calcium uptake in GH3 rat pituitary cells; inhibits HIV-1 replication in H9 cells (EC50 = 4.6 µM); inhibits IL-1β-induced production of IL-6 in A549 cells and reduces iNOS levels and LPS-induced NO production in MH-S cells; decreases the number of alveolar and interstitial macrophages and alveolar wall thickness in a mouse model of LPS-induced lung inflammation from 20-60 mg/kg; reduces formalin-induced paw licking in mice at 10 mg/kg

Formal name: (2Z)-2-methyl-2-butenoic acid, 1-[(8S)-8,9-dihydro-2-oxo-2H-furo[2,3-h]-1-benzopyran-8-yl]-1-methylethyl ester

Synonyms:  Columbianetin

Molecular weight: 328.4

CAS: 5058-13-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Neuroscience|Pain Research

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