A coumarin with diverse biological activities; active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 µg/ml); inhibits LPS-induced NO production (IC50 = 5.9 µM) and reduces COX-2 protein levels in RAW 264.7 cells; completely inhibits arachidonic acid-

Collinin – 1 mg

Brand:
Cayman
CAS:
34465-83-3
Storage:
-20
UN-No:
Non-Hazardous - /

Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.{46733,46734,46735,46736} It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 µg/ml).{46733} Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 µM) and reduces COX-2 protein levels in RAW 264.7 cells.{46734} It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), collagen, or platelet activating factor (PAF) when used at a concentration of 100 µM.{46735} Dietary administration of collinin (0.05% w/w) reduces the number of mice with tumors and the number of tumors per mouse in a mouse model of colitis-related carcinogenesis.{46736}  

 

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SKU: 29946 - 1 mg Category:

Description

A coumarin with diverse biological activities; active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 µg/ml); inhibits LPS-induced NO production (IC50 = 5.9 µM) and reduces COX-2 protein levels in RAW 264.7 cells; completely inhibits arachidonic acid-, collagen-, or PAF-induced aggregation of isolated rabbit platelets at 100 µM; dietary administration reduces the number of mice with tumors and the number of tumors per mouse in a mouse model of colitis-related carcinogenesis at 0.05% w/w

Formal name: 7-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-8-methoxy-2H-1-benzopyran-2-one

Synonyms:  NSC 31870

Molecular weight: 328.4

CAS: 34465-83-3

Purity: ≥95%

Formulation: A solid

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