An antibiotic; inhibits the growth of a variety of Gram-negative (MICs = 0.04-2.08 µg/ml) and some Gram-positive bacteria (MICs = 2.5-10 µg/ml); inhibits the growth of clinical isolates of both susceptible and multidrug-resistant P. aeruginosa (MICs = 1-2 mg/l); binds selectively to LPS from susceptible strains of K. pneumoniae compared to resistant strains (Kis = 0.56 and 2.83 µM

Colistin – 25 mg

Brand:
Cayman
CAS:
1066-17-7
Storage:
-20
UN-No:
Non-Hazardous - /

Colistin is a complex antibiotic containing greater than 30 components, with the cyclic polypeptide antibiotics polymyxins E1 (colistin A) and E2 (colistin B) as the major components.{40859,43058} It was originally isolated from B. polymyxa.{40859} Colistin inhibits the growth of the Gram-negative bacteria E. coli, P. aeruginosa, P. fluorescens, and S. enterica (MICs = 0.04-2.08 μg/ml) and Gram-positive L. ivanovii and L. monocytogenes (MICs = 2.5-10 μg/ml) but is not active against Gram-positive L. lactis, P. polymyxa, P. acidilactici, or S. aureus at concentrations up to 5 μg/ml.{40860} It also inhibits the growth of clinical isolates of both susceptible and multidrug-resistant P. aeruginosa (MICs = 1-2 mg/l).{40861} Colistin binds selectively to LPS from susceptible strains of K. pneumoniae compared to resistant strains (Kis = 0.56 and 2.83 μM, respectively), which may contribute to its mechanism of action against Gram-negative bacteria.{40863} In vivo, colistin slows the growth of P. aeruginosa and A. baumannii in a neutropenic mouse model of thigh infection.{40862}  

 

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SKU: 23487 - 25 mg Category:

Description

An antibiotic; inhibits the growth of a variety of Gram-negative (MICs = 0.04-2.08 µg/ml) and some Gram-positive bacteria (MICs = 2.5-10 µg/ml); inhibits the growth of clinical isolates of both susceptible and multidrug-resistant P. aeruginosa (MICs = 1-2 mg/l); binds selectively to LPS from susceptible strains of K. pneumoniae compared to resistant strains (Kis = 0.56 and 2.83 µM, respectively); inhibits growth of P. aeruginosa and A. baumannii strains in a neutropenic mouse model of thigh infection

Formal name:

Synonyms:  Polymyxin E Complex

Molecular weight: 1,169.50

CAS: 1066-17-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Polypeptides||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Typhoid

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