A colchicine derivative that inhibits tubulin polymerization (IC50 = 2.1 μM) with low toxicity; suppresses microtubule dynamicity

Colcemid – 5 mg

Brand:
Cayman
CAS:
477-30-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Colcemid is a colchicine (Item No. 9000760) derivative that inhibits tubulin polymerization as potently as colchicine (IC50 = 2.1 and 2.4 μM, respectively) but is less toxic.{24891,24890,24892} At very low (nanomolar) concentrations, colcemid suppresses microtubule dynamicity and inhibits cell migration, while at micromolar levels it blocks microtubule assembly, arresting cells in metaphase.{24892,24893,24888} Mitotic block by colcemid is used to synchronize cells and for karyotyping in cytogenetic studies.{24893,24894} Prolonged exposure to colcemid can activate p53, leading to apoptosis.{24889}  

 

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Description

A colchicine derivative that inhibits tubulin polymerization (IC50 = 2.1 μM) with low toxicity; suppresses microtubule dynamicity, inhibits cell migration, blocks microtubule assembly, and arrests cells in metaphase; used to synchronize cells and for karyotyping in cytogenetic studies

Formal name: (7S)-6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one

Synonyms:  Demecolcine|NSC 3096

Molecular weight: 371.4

CAS: 477-30-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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