An inhibitor of DGK (Ki = 3.1 µM) and DGAT (IC50 = 5.6 µM); reduces the concentration of phosphatidic acid in T cell lymphoma (IC50 = 3 µM); binds to human CCR5 chemokine receptors with an IC50 value of 11 µM

Cochlioquinone A – 2.5 mg

Brand:
Cayman
CAS:
32450-25-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 µM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 µM).{31097,31096,31098} It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 µM.{31097} It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 µM.{31098}  

 

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Description

An inhibitor of DGK (Ki = 3.1 µM) and DGAT (IC50 = 5.6 µM); reduces the concentration of phosphatidic acid in T cell lymphoma (IC50 = 3 µM); binds to human CCR5 chemokine receptors with an IC50 value of 11 µM

Formal name: (3R,4aR,6aR,12S,12aS,12bR)-9-[(1S,2R,3S)-2-(acetyloxy)-1,3-dimethylpentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-3-(1-hydroxy-1-methylethyl-6a,12b-dimethyl-pyrano[3,2-a]xanthene-8,11-dione

Synonyms: 

Molecular weight: 532.7

CAS: 32450-25-2

Purity: ≥99%

Formulation: A yellow lyophilisate

Product Type|Biochemicals|Kinase Inhibitors|Other Lipid Kinases||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Acyltransferases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity

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